What is the Use of Sofosbuvir and Velpatasvir Tablets? Sofosbuvir and velpatasvir are both used in combination with each other for the treatment of Hepatitis C (HCV). They are together also known as Epclusa. Sofosbuvir is a nucleotide polymerase inhibitor as it functions by blocking the action of RNA polymerase. Consequently, it stops the viral replication. Velpatasvir on the other hand is an HCV replication complex inhibitor. Both medication stop...